Mechanical properties of MDCK II cells exposed to gold nanorods

• Anna Pietuch,
• Bastian Rouven Brückner,
• David Schneider,
• Marco Tarantola,
• Christina Rosman,
• Carsten Sönnichsen and
• Andreas Janshoff

Beilstein J. Nanotechnol. 2015, 6, 223–231, doi:10.3762/bjnano.6.21

• CTAB coated rods suggesting an increase in acoustic load corresponding to a larger stiffness (storage modulus). Keywords: atomic force microscopy; CTAB; gold nanorods; membrane tension; MDCK II cells; QCM; Introduction The interest in gold nanoparticles (NP) for biomedical applications in the field

• /m. Considering these extremely stiff cells at high CTAB coated gold nanorods concentrations as liquid droplets is probably no longer justified. It is difficult to explain these extraordinary high values in terms of cortical or even membrane tension and inextensibility of the plasma membrane alone

Intake of silica nanoparticles by giant lipid vesicles: influence of particle size and thermodynamic membrane state

• Florian G. Strobl,
• Florian Seitz,
• Christoph Westerhausen,
• Armin Reller,
• Adriano A. Torrano,
• Christoph Bräuchle,
• Achim Wixforth and
• Matthias F. Schneider

Beilstein J. Nanotechnol. 2014, 5, 2468–2478, doi:10.3762/bjnano.5.256

• membrane area is consumed during the wrapping process. Dietrich et al. introduced a model for vesicle–particle interaction in the large particle limit in which the wrapping process is mainly limited by the membrane tension [20]. This model is confirmed by experiments with latex beads in the micrometer

• Equation 2 in [33]). Assuming a surface to surface distance of 0.5 nm ≤ d ≤ 1 nm, ga ≈ gdl ≈ −1 mJ/m2 can serve as an upper limit for the attractive adhesion energy. Rising membrane tension upon particle uptake Assuming a process as described in Figure 1, the uptake of one particle with radius r will

• than the simple area-loss argument suggests. Discussion Why are small particles preferred for an uptake over large ones and why is an uptake of large particles only possible for gel phase vesicles? This question will be discussed here seperately with regard to membrane tension and to bending stiffness

Nanoparticle interactions with live cells: Quantitative fluorescence microscopy of nanoparticle size effects

• Li Shang,
• Karin Nienhaus,
• Xiue Jiang,
• Linxiao Yang,
• Katharina Landfester,
• Volker Mailänder,
• Thomas Simmet and
• G. Ulrich Nienhaus

Beilstein J. Nanotechnol. 2014, 5, 2388–2397, doi:10.3762/bjnano.5.248

• ligand densities and the receptor-ligand binding energy. It competes with the energy cost required to bend the membrane, which depends on the membrane tension and the NP curvature and, therefore, on the NP size. If the overall energy balance is equivalent to a localized decrease in the Gibbs free energy